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Of those with a low TSH, most were mildly low, but 31 of 58 patients (53%) had elevated FreeT 4 levels indicating overt hyperthyroidism. Of those with abnormal thyroid tests, 58 (20.2%) showed lab tests consistent with hyperthyroidism (low TSH) and 15 (5.2%) with hypothyroidism (high TSH). A marker of inflammation (Interleukin- 6 (IL-6)) was also measured.Ī total of 287 patients were included in the study, of which 214 (74.6%) demonstrated normal thyroid function. TSH was measured routinely and Free T 4 and Free T 3 levels were assessed if the TSH was abnormal. Additionally, patients were not included if they were taking drugs known to alter thyroid function or if they were critically ill requiring ventilator support. They excluded all patients who were on treatment for either hyperthyroidism or hypothyroidism. This study is a medical record review that examines thyroid function in patients hospitalized in one center in Italy with COVID-19 infection. Thyrotoxicosis in patients with COIVD-19: the THYRCOV study. Lania A et al on behalf of Humanitas COVID-19 Task Force. The aim of this study was to evaluate the frequency subacute thyroiditis in COVID-19 patients as compared to non-COVID patients admitted to the intensive care unit in Italy. Muller et al report the association of subacute thyroiditis and COVID-19. The goal of the study was to assess thyroid function in all patients admitted to the hospital with confirmed COVID-19 to determine if this infection was associated with abnormalities in thyroid function. Lania et al sought to characterize thyroid function in patients hospitalized with COVID-19 infection. These 2 studies report changes in thyroid function in patients with COVID-19 infection. The thyroid also can be affected indirectly as a result of the overall severity of the infection. Since the most common causes of thyroid problems result from antibodies attacking the thyroid (autoimmune thyroid disease), this immune system activation may also cause inflammation and dysfunction of the thyroid. ![]() In some patients, infection with COVID-19 may cause a hypersensitive immune reaction and widespread inflammation known as a “cytokine storm”. Along with multiple organ systems that may be affected by COVID-19 is the thyroid gland. COVID-19 infection can range from a very mild or asymptomatic presentation to critical illness and death. ![]() A novel coronavirus known as severe acute respiratory syndrome coronavirus-2 (SARS-COV-2) is responsible for the coronavirus 19 (COVID-19) global pandemic that began in late 2019. |
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